Table 2.

The three GWAS-significant (P<5×10⁻⁸) variants for lung cancer in European ancestry never smokers, found in the joint analysis of the original discovery set, the never smoker subset of the OncoArray set, and the replication set (6 clusters, 3636 cases, 6295 controls), adjusted for age, sex, and the first five principal components.

SNP ID	CHR*	Position	Odds Ratio*	95% CI		P-value*	Reference allele	Effect allele	EAF*	Gene symbol
				Lower boundary	Upper boundary
rs380286**	5	1320247	0.770	0.723	0.820	4.32×10−16	A	G	0.4169	CLPTM1L
rs31490†	5	1344458	0.769	0.722	0.820	5.31×10−16	G	A	0.4142	CLPTM1L
rs4975616‡	5	1315660	0.778	0.730	0.829	1.04×10−14	G	A	0.4005	CLPTM1L

^*Adjusted for age, gender, and the first 5 principal components; CHR, chromosome; EAF, effect allele frequency

^**intronic variant

^†splice variant

^‡downstream gene variant