Table 3.
Previous findings from the association analyses of lung cancer in never smokers, with a comparison to this study
| Previously Published Studies | This Study* | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Region | Gene | RefSeq* | Study type | Pubmed ID | Histology | Ethnicity | Discovery cases | controls | Replication cases | controls | OR* | P-value | OR | P-value |
| 13q31.3 | GPC5 | rs2352028 | GWAS* | Li et al 17 | NSCLC | Mostly Eur. descent | 377 | 377 | 328 | 407 | 1.46 | 5.90E-06 | 0.99 | 0.95 |
| 5p15.33 | CLPTM1L | rs4975616 | Candidate | Wang et al 15 | NSCLC | Eur. descent | 239 | 553 | - | 0.69 | 7.90E-04 | 0.78 | 1.04E-14 |
| 5p15.33 | CLPTM1L-TERT | rs2736100 | GWAS | Hsiung et al 9 | Adeno | Asian women | 584 | 585 | 2184 | 12515 | 1.5 | 5.40E-11 | 1.3 | 2.66E-09 |
| 10q25.2 | VTI1A | rs7086803 | GWAS | Lan et al 10 | NSCLC | Asian women | 5547 | 4492 | 1085 | 2877 | 1.3 | 5.10E-17 | 1.3 | 0.011 |
| 6q22.2 | ROS1-DCBLD1 | rs9387478 | 0.85 | 7.80E-08 | 0.86 | 1.50E-04 | ||||||
| 6p21.32 | HLA II | rs2395185 | 1.16 | 2.60E-06 | 1.04 | 0.34 | ||||||
| 5p15.33 | CLPTM1L-TERT | rs2736100 | 1.38 | 4.20E-27 | 1.27 | 2.66E-09 | ||||||
| 5p15.33 | CLPTM1L-TERT | rs2853677 | GWAS | Shiraishi et al 12 | Adeno | Asians (Japanese) | 1695 | 5333 | 3328 | 8168 | 1.44 | 3.90E-23 | 1.28 | 1.12E-09 |
| 5p15.33 | CLPTM1L-TERT | rs2736100 | 1.37 | 9.90E-19 | 1.27 | 2.66E-09 | ||||||
| 3q28 | TP63 | rs10937405 | 1.28 | 2.00E-10 | 1.16 | 1.50E-04 | ||||||
| 17q24.3 | BPTF | rs7216064 | 1.21 | 1.50E-06 | 1.1 | 0.054 | ||||||
| 6p21.3 | BTNL2 | rs3817963 | 1.21 | 1.50E-07 | 1.06 | 0.2 | ||||||
| 1q25.1 | ACVR1B | rs10127728 | Candidate | Spitz et al 14 | NSCLC | Mostly Eur. descent | 451 | 508 | - | 1.68 | 3.00E-04 | 1.06 | 0.34 |
| 3q28 | TP63 | rs4488809 | Replication of GWAS findings | Seow et al 11 | Adeno | Asian women | 7448 | 7007 | 0.8 | 4.30E-17 | 0.82 | 8.52E-07 | |
| 5p15.33 | TERT | rs2736100 | 7505 | 7070 | 1.43 | 6.12E-43 | 0.79 | 2.66E-09 | |||||
| 6p21.1 | FOXP4 | rs7741164 | 10531 | 10648 | 1.17 | 3.96E-13 | 0.97 | 8.28E-01 | |||||
| 6p21.3 | BTNL2 | rs3817963 | 7255 | 6745 | 1.16 | 1.63E-07 | 1.06 | 1.97E-01 | |||||
| 6p21.32 | HLA-DPB1 | rs2179920 | 7457 | 7020 | 1.17 | 1.69E-05 | 1.08 | 9.42E-02 | |||||
| 6p21.32 | HLA class II | rs2395185 | 7757 | 9637 | 1.16 | 2.04E-09 | 1.04 | 3.91E-01 | |||||
| 6q22.2 | ROS1/DCBLD1 | rs9387478 | 8022 | 9970 | 0.86 | 5.25E-11 | 0.86 | 1.53E-04 | |||||
| 9p21.3 | rs72658409 | 10780 | 10938 | 0.76 | 2.37E-10 | 0.89 | 1.43E-01 | ||||||
| 10q25.2 | VTI1A | rs7086803 | 7964 | 9914 | 1.25 | 9.22E-17 | 1.31 | 1.12E-02 | |||||
| 12q13.13 | rs11610143 | 10267 | 10634 | 0.85 | 3.55E-13 | 0.97 | 4.88E-01 | ||||||
| 17q24.3 | BPTF | rs7216064 | 7720 | 8630 | 0.86 | 6.19E-09 | 1.10 | 5.43E-02 | |||||
*
”This study” pertains to the results of the meta-analysis of the discovery and OncoArray sets, except for rs4975616, for which the result from the meta-analysis of the discovery, OncoArray, and replication sets is shown; RefSeq, Reference sequence or SNP ID; GWAS, genome wide association study; OR, odds ratio; nominally significant p-values are shown in bold