Table 1.
Channel | S3 Flexibility index(1/mBf) |
S3-S4 Flexibility index (1/mBf) | S1-S4 Flexibility index (1/mBf) |
Charge per channel (e0) | Q10 (τact) |
Q10 (τinact) |
References |
---|---|---|---|---|---|---|---|
Shaker Kv | 1.48 | 1.96 | 1.87 | 12 – 16 | ~ 4 | 7.2 | [44,107,121–125] |
Kv1.2 | 1.61 | 1.86 | 1.82 | 10 | n.d. | n.d. | [125] |
Na+-channel (frog muscle) | – | – | – | ~ 12 | 2.4 | 3–5.3 | [126,127] |
Na+-channel (muscle) | – | – | – | ~ 12 | 2.3 | 3.4–9.1 | [126,127] |
Nav1.5 DI | 1.56 | 1.69 | 1.67 | ~ 12 | 1.25 | 4 ; 5.8a | [82] |
Nav1.5 DIV | 1.51 | 1.62 | 1.68 | ~ 12 | 1.25 | 4 ; 5.8a | [82] |
Ca2+-channel (muscle) | – | – | – | 8.6 – 15b | ~ 3.0 | n.d. | [128,129] |
Cav 1.2 DII | 1.58 | 1.70 | 1.67 | ~ 9 | n.d.c | 3d | [129,130] |
Cav 1.2 DIV | 1.62 | 1.90 | 1.70 | ~ 9 | n.d.c | 3d | [129,130] |
Cav 1.4 DII | 1.66 | 1.68 | 1.65 | ~ 9 | n.d.c | ~ 19e | [129,130] |
Cav 1.4 DIV | 1.62 | 1.97 | 1.75 | ~ 9 | n.d.c | ~ 19e | [129,130] |
Kv7.4 (KCNQ4) | 1.53 | 1.62 | 1.58 | ~ 8 | 8.3 | n.d. | [81] |
Kv11.3 | 1.56 | 1.84 | 1.81 | 8 | 3.8 | 2.6 | [131] |
Kv11.1 (hERG) | 1.51 | 1.80 | 1.74 | 6 – 8 | 4.7 | 2.9 | [131,132] |
HCN2 | 1.63 | 1.73 | 1.80 | 5 – 8f | n.d. | n.d. | [133] |
HCN1 | 1.62 | 1.73 | 1.78 | 3.75 | 2.9 | 3.1g | [134] |
hHv1 | 1.40 | 1.49 | 1.50 | 6 | 6 – 9 | – | [115,135] |
mHv1 | 1.40 | 1.46 | 1.49 | 4 | 6 – 9 | – | [115,136] |
BK (Slo1) | 1.55 | 1.67 | 1.64 | 2.4–4.4 | n.d. | n.d. | [137–139] |
ciVSP | 1.52 | 1.63 | 1.66 | ~ 1.25 | 1.4 | 1.7 g | [140] |
mTRPM8 | 1.51 | 1.59 | 1.60 | 0.9 | 1.2 | 5.2–9.4 h | [47,141,142] |
mTRPA1 | 1.50 | 1.45 | 1.69 | n.d. | 2.8 | – | [143] |
DmTRPA1 | 1.47 | 1.54 | 1.72 | n.d. | 11 | – | [143] |
TRPV1 | 1.44 | 1.52 | 1.66 | 0.5–0.7 | ~ 15 – 40 | 1.35 g | [47,55,144] |
TRPV2 | 1.49 | 1.52 | 1.55 | n.d. | >100 | – | [64] |
CNGA1 | 1.77 | 1.93 | 1.82 | ~ 0.22 | n.d. | – | [145] |
CNGA2 | 1.64 | 1.78 | 1.68 | n.d. | 2 – 6 i | – | [108] |
Notes for Table 1
aQ10 at −70mV or −50mV
bCharge per channel depends on the β subunit used. α1E and α1E β1a gave high e0 values (~15)
cHowever, increasing the temperature from 23°C to 37°C increases whole-cell conductance and shifts the voltage-dependence of activation to more hyperpolarized voltages [130]
dCav1.2 inactivation kinetics are not strongly temperature-dependent [130]
eInactivation is more sensitive to lower temperature changes, compared with those at higher temperatures (i.e. 23–33°C vs. 27–37°C [130])
fBinding of cAMP to the channels stabilizes the open pore, reducing the total gating charge from ~8 to ~5
gQ10 for the deactivation rate
hQ10 estimations for the deactivation rate, including slow and fast components
iMean Q10 exhibits a maximum of ~6 only at [cGMP]/EC50 near 0.1 [108]