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. 2019 Oct 24;13(1):455–476. doi: 10.1080/19336950.2019.1674242

Table 1.

Comparison between local flexibility, voltage dependence and temperature coefficient for selected ion channels.

Channel S3
Flexibility index(1/mBf)
S3-S4 Flexibility index (1/mBf) S1-S4
Flexibility index (1/mBf)
Charge per channel (e0) Q10
act)
Q10
inact)
References
Shaker Kv 1.48 1.96 1.87 12 – 16 ~ 4 7.2 [44,107,121125]
Kv1.2 1.61 1.86 1.82 10 n.d. n.d. [125]
Na+-channel (frog muscle) ~ 12 2.4 3–5.3 [126,127]
Na+-channel (muscle) ~ 12 2.3 3.4–9.1 [126,127]
Nav1.5 DI 1.56 1.69 1.67 ~ 12 1.25 4 ; 5.8a [82]
Nav1.5 DIV 1.51 1.62 1.68 ~ 12 1.25 4 ; 5.8a [82]
Ca2+-channel (muscle) 8.6 – 15b ~ 3.0 n.d. [128,129]
Cav 1.2 DII 1.58 1.70 1.67 ~ 9 n.d.c 3d [129,130]
Cav 1.2 DIV 1.62 1.90 1.70 ~ 9 n.d.c 3d [129,130]
Cav 1.4 DII 1.66 1.68 1.65 ~ 9 n.d.c ~ 19e [129,130]
Cav 1.4 DIV 1.62 1.97 1.75 ~ 9 n.d.c ~ 19e [129,130]
Kv7.4 (KCNQ4) 1.53 1.62 1.58 ~ 8 8.3 n.d. [81]
Kv11.3 1.56 1.84 1.81 8 3.8 2.6 [131]
Kv11.1 (hERG) 1.51 1.80 1.74 6 – 8 4.7 2.9 [131,132]
HCN2 1.63 1.73 1.80 5 – 8f n.d. n.d. [133]
HCN1 1.62 1.73 1.78 3.75 2.9 3.1g [134]
hHv1 1.40 1.49 1.50 6 6 – 9 [115,135]
mHv1 1.40 1.46 1.49 4 6 – 9 [115,136]
BK (Slo1) 1.55 1.67 1.64 2.4–4.4 n.d. n.d. [137139]
ciVSP 1.52 1.63 1.66 ~ 1.25 1.4 1.7 g [140]
mTRPM8 1.51 1.59 1.60 0.9 1.2 5.2–9.4 h [47,141,142]
mTRPA1 1.50 1.45 1.69 n.d. 2.8 [143]
DmTRPA1 1.47 1.54 1.72 n.d. 11 [143]
TRPV1 1.44 1.52 1.66 0.5–0.7 ~ 15 – 40 1.35 g [47,55,144]
TRPV2 1.49 1.52 1.55 n.d. >100 [64]
CNGA1 1.77 1.93 1.82 ~ 0.22 n.d. [145]
CNGA2 1.64 1.78 1.68 n.d. 2 – 6 i [108]

Notes for Table 1

aQ10 at −70mV or −50mV

bCharge per channel depends on the β subunit used. α1E and α1E β1a gave high e0 values (~15)

cHowever, increasing the temperature from 23°C to 37°C increases whole-cell conductance and shifts the voltage-dependence of activation to more hyperpolarized voltages [130]

dCav1.2 inactivation kinetics are not strongly temperature-dependent [130]

eInactivation is more sensitive to lower temperature changes, compared with those at higher temperatures (i.e. 23–33°C vs. 27–37°C [130])

fBinding of cAMP to the channels stabilizes the open pore, reducing the total gating charge from ~8 to ~5

gQ10 for the deactivation rate

hQ10 estimations for the deactivation rate, including slow and fast components

iMean Q10 exhibits a maximum of ~6 only at [cGMP]/EC50 near 0.1 [108]