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. 2019 Aug 13;220(12):1926–1934. doi: 10.1093/infdis/jiz399

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Published by Oxford University Press for the Infectious Diseases Society of America 2019.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 5. — Correlation between secreted cytokines and chemokines in hepatitis B surface antigen (HBsAg)–specific T cells induced by vaccination and levels of antibody to HBsAg. Spearman correlation tests were performed. Dots represent correlation tests in the group receiving dissolvable microneedle patch delivery of adjuvant-free hepatitis B vaccine (AFV) (A), in the intramuscular AFV group (B), and in the intramuscular aluminum-adjuvanted hepatitis B vaccine group (C). Abbreviations: Abbreviations: IFN, interferon; IL-1β, interleukin 1β; IL-6, interleukin 6; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; OD₄₅₀, optical density at 450 nm; TGF, transforming growth factor.