Figure 5.

In vivo effects of paeoniflorin on arterial thrombosis and bleeding time. (A) Ex vivo effects of paeoniflorin on SIPA in freshly isolated rat platelets, which were collected from SD rats following the intravenous treatment with paeoniflorin for 30 min (n = 5). (B) In vivo effects of paeoniflorin on thrombin time (PT), and activated partial prothrombin time (aPTT) (n = 5). (C) In vivo effects of paeoniflorin on time to occlusion the in rat arterial thrombosis model induced by FeCl₃ (n = 5). (D) Effects of paeoniflorin on bleeding time in rat tail transection model. The in vivo efficacy of paeoniflorin was compared to that of clopidogrel (CLO) at the dose of 25 mg/kg by oral administration (n = 5). Values are mean ± SEM (expressed as the error bar) of at the independent experiments from different animals. *, significant differences from control group (p < 0.05).