Figure 4.

(a) Analysis of the primary amino acid sequences of human TSLP, IL-21, MCP3, MIP-1b, eotaxin, and mouse TSLP. The amino acid sequences of the five cytokines and chemokines that were efficiently cleaved by the human skin tryptase are shown in one letter code. Negatively charged residues are marked in green and positively charged in red. The regions that are highly positively charged and that may act as targets for the tryptase are marked by a red thick line. In (b) an alignment of human, dog, mouse, and rat TSLP is presented. The conserved residues between the majority of the four sequences are marked in black. The positively charged patch found in human and dog TSLP is marked in red for more easy identification.