Table 1.
Summary of the results from the cleavage analysis of cytokines and chemokines by the human and mouse tryptases and the hMC chymase (HC).
| Cytokine | hTryp. | M6 | HC | Cytokine | hTryp. | M6 | HC |
|---|---|---|---|---|---|---|---|
| IL-4 | − | − | − | IL-1α | − | − | |
| IL-5 | − | − | − | IL-1β | − | − | − |
| IL-10 | − | − | − | IL-1RA | + | ||
| TSLP | ++++ | − | + | IL-33 | − | + | ++++ |
| IL-13 | − | +++ | + | IL-18 | − | +++ | |
| SCF | − | − | − | IGF-1 | − | ++++ | |
| IL-3 | − | − | + | IGF-2 | − | ||
| IL-31 | − | − | − | HGF | − | ||
| GM-CSF | − | + | − | IL-8 | ++ | − | |
| M-CSF | − | − | IP-10 | − | ++++ | − | |
| G-CSF | − | − | − | MCP-1 | − | + | − |
| TGF- β3 | − | MCP-2 | − | − | |||
| TNF-α | − | − | − | MCP-3 | ++++ | − | |
| IL-6 | − | + | ++ | RANTES | − | − | − |
| IL-11 | − | + | + | SDF-1α | − | ++ | − |
| LIF | − | − | + | SDF-1β | + | − | − |
| IL-2 | − | − | − | EGF | − | − | − |
| IFN-γ | +++ | + | + | MIP-1α | − | − | - |
| IL-15 | − | − | ++++ | flt3L | − | + | ++ |
| IL-12 | − | − | FGF-9 | − | |||
| IL-20 | + | − | − | FGF-19 | − | ||
| IL-7 | + | + | − | BMP-14 | − | ||
| IL-21 | ++++ | ++++ | − | GAL-7H | − | ||
| IL-16 | − | − | pF4V1 | − | |||
| VEGF-A | + | ++++ | − | IL-25 | − | − | − |
| VEGF-121 | − | IL-9 | − | ++++ | |||
| PDGF-A | − | + | − | MIP-3a | − | ++++ | |
| PDGF-B | − | +++ | − | MIP-3b | ++++ | ++++ | |
| BMP-2 | − | Eotaxin | +++ | ++++ | |||
| CTGF | ++ | + | IL-27A | - | |||
| FGF-1 | + | − | + | IL17C | ++++ | ||
| FGF-2 | − | + | + | NGF-β | − | ||
| IL-17A | + | − | − | TPO | + | ||
| IL-17F | + | + | − | GRO-a | − | ||
| IL-22 | − | − | − | GRO-b | − | ||
| CD40L | − | + | − | MIP-1b | − | ||
| BAFF | − | + | |||||
| IL-19 | − | − | − | ||||
| sIL-6R | − | ||||||
| CNTF | − |
All the results concerning the MC chymase originate from an earlier study [17]. The analysis is based on the SDS-PAGE analysis in Figure 2 and Figure 3. (−) no cleavage activity was observed. (+) showed minor activity, (++) and (+++) partial cleavage. (++++) complete or almost complete cleavage by the enzyme.