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Acute hepatic inflammation in LXRα/β-knockout mice. Lipopolysaccharide (LPS) administration stimulates inflammatory cytokine production and recruitment of F4/80loCD11b+ bone marrow-derived macrophages (BMDMs) in the liver of LXRα/β-knockout mice more effectively than in wild-type mice [80]. LXRs regulate acute hepatic inflammatory responses. ↑, increase.
