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. 2019 Nov 6;14(11):e0224726. doi: 10.1371/journal.pone.0224726

Fig 4. Photomicrographs of lung biopsy demonstrating metastatic MpBC with squamous differentiation invading lung parenchyma.

Fig 4

(A) Hematoxylin-eosin staining (original magnification 4X), (B) Hematoxylin-eosin staining (original magnification 20X), (C) IHC showing tumor cells are positive for GCDFP-15 (original magnification 20X), and (D) IHC showing tumor cells are negative for TTF-1 (original magnification 20X), consistent with MpBC. MpBC, metaplastic breast cancer; IHC, immunohistochemistry; GCDFP-15, gross cystic disease fluid protein 15; TTF-1, thyroid transcription factor-1.