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Release of isoforms of the degradative enzyme MMP-1 (a), −3 (b), −9 (c), −10 (d), and −13 (e) (normalized by DNA) from OA FLS monolayers treated for 6 days with IL-1α (IL-1), TNF-α (TNF), or cartilage wear particles (CWP), with untreated controls (CTL). N = 9 (a), 6 (b), 8 (c), 7 (d), and 9 (e) donors. *p < 0.05 vs. CTL, **p < 0.05 vs. CTL and CWP, ***p < 0.05 vs. CTL, CWP, and TNF.
