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. 2019 Oct 26;11(20):8777–8791. doi: 10.18632/aging.102264

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Copyright © 2019 Yang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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BMSCs-derived exosomal MALAT1 promotes osteoblast activity. (A) The MALAT1 expression in exosomes evaluated by RT-qPCR. (B) The MALAT1 and miR-34c expression in hFOB1.19 detected by RT-qPCR. (C) The protein expression of SATB2, Runx2, ATF4 and Hoxa2 in osteoblasts (hFOB1.19) treated with oe-MALAT1 detected by Western blot analysis. (C) Alizarin red staining of osteoblasts (hFOB1.19) treated with oe-MALAT1 (200 ×). L. ALP staining of osteoblasts (hFOB1.19) treated with oe-MALAT1 (200 ×). * p < 0.05 vs. oe-NC. Data were expressed with mean ± standard error. In Panel A–C, the unpaired t test was used for data analysis. The experiment was repeated three times.