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. 2019 Oct 26;11(20):9043–9059. doi: 10.18632/aging.102372

Table 1. Functional and pathway enrichment analysis of up-regulated and down-regulated genes among four datasets.

Expression Category Term Count % P Value
up-regulated GOTERM_BP_DIRECT GO:0007067~mitotic nuclear division 18 38.29787234 1.28E-20
GOTERM_BP_DIRECT GO:0051301~cell division 17 36.17021277 1.39E-16
GOTERM_BP_DIRECT GO:0007062~sister chromatid cohesion 9 19.14893617 1.85E-10
GOTERM_BP_DIRECT GO:0000086~G2/M transition of mitotic cell cycle 9 19.14893617 1.82E-09
GOTERM_BP_DIRECT GO:0007059~chromosome segregation 7 14.89361702 1.91E-08
GOTERM_CC_DIRECT GO:0005819~spindle 11 23.40425532 2.99E-13
GOTERM_CC_DIRECT GO:0030496~midbody 10 21.27659574 2.40E-11
GOTERM_CC_DIRECT GO:0005874~microtubule 11 23.40425532 3.41E-09
GOTERM_CC_DIRECT GO:0000775~chromosome, centromeric region 7 14.89361702 5.29E-09
GOTERM_CC_DIRECT GO:0000776~kinetochore 7 14.89361702 4.53E-08
GOTERM_MF_DIRECT GO:0005515~protein binding 41 87.23404255 9.05E-10
GOTERM_MF_DIRECT GO:0005524~ATP binding 18 38.29787234 3.45E-08
GOTERM_MF_DIRECT GO:0003777~microtubule motor activity 7 14.89361702 4.29E-08
GOTERM_MF_DIRECT GO:0008017~microtubule binding 8 17.0212766 7.29E-07
GOTERM_MF_DIRECT GO:0004674~protein serine/threonine kinase activity 8 17.0212766 3.54E-05
KEGG_PATHWAY hsa04110:Cell cycle 6 12.76595745 1.97E-06
KEGG_PATHWAY hsa04114:Oocyte meiosis 4 8.510638298 9.73E-04
KEGG_PATHWAY hsa04115:p53 signaling pathway 3 6.382978723 0.00674313
KEGG_PATHWAY hsa04914:Progesterone-mediated oocyte maturation 3 6.382978723 0.01117001
KEGG_PATHWAY hsa05203:Viral carcinogenesis 3 6.382978723 0.05510903
down-regulated GOTERM_BP_DIRECT GO:0007268~chemical synaptic transmission 16 14.15929204 1.58E-11
GOTERM_BP_DIRECT GO:0007269~neurotransmitter secretion 6 5.309734513 1.41E-05
GOTERM_BP_DIRECT GO:0006836~neurotransmitter transport 5 4.424778761 1.73E-05
GOTERM_BP_DIRECT GO:1902476~chloride transmembrane transport 7 6.194690265 2.15E-05
GOTERM_BP_DIRECT GO:0006811~ion transport 7 6.194690265 1.24E-04
GOTERM_CC_DIRECT GO:0030054~cell junction 25 22.12389381 1.97E-16
GOTERM_CC_DIRECT GO:0030672~synaptic vesicle membrane 10 8.849557522 3.25E-11
GOTERM_CC_DIRECT GO:0005886~plasma membrane 52 46.01769912 1.47E-08
GOTERM_CC_DIRECT GO:0048786~presynaptic active zone 6 5.309734513 7.06E-07
GOTERM_CC_DIRECT GO:0008021~synaptic vesicle 8 7.079646018 1.22E-06
GOTERM_MF_DIRECT GO:0004890~GABA-A receptor activity 4 3.539823009 1.88E-04
GOTERM_MF_DIRECT GO:0005509~calcium ion binding 14 12.38938053 3.42E-04
GOTERM_MF_DIRECT GO:0005230~extracellular ligand-gated ion channel activity 4 3.539823009 9.96E-04
GOTERM_MF_DIRECT GO:0044325~ion channel binding 5 4.424778761 0.00472253
GOTERM_MF_DIRECT GO:0048306~calcium-dependent protein binding 4 3.539823009 0.00505404
KEGG_PATHWAY hsa05033:Nicotine addiction 7 6.194690265 2.30E-07
KEGG_PATHWAY hsa04723:Retrograde endocannabinoid signaling 9 7.96460177 3.09E-07
KEGG_PATHWAY hsa04727:GABAergic synapse 8 7.079646018 1.40E-06
KEGG_PATHWAY hsa05032:Morphine addiction 7 6.194690265 3.07E-05
KEGG_PATHWAY hsa04721:Synaptic vesicle cycle 6 5.309734513 6.13E-05