Table 2.

Brain Activation during Low Back Pressure Stimulation in Macaques after Chymopapain Treatment Over Time.

Area	Hemisphere	Z value	Coordinates (mm)
			x	y	z
Pretreatment
SII and Ins	Right	0.22	−16	18	4
	Left	0.29	18	16	6
Thalamus	Right	0.15	8	−2	8
	Left	0.17	−6	−4	8
Cingulate cortex		0.24	0	−20	−10
Day 1 after chymopapain
SII and Ins	Right	1.98*	−14	16	4
	Left	2.72*	16	16	6
Thalamus	Right	0.32	4	−4	6
	Left	0.22	−6	−2	4
Cingulate cortex		1.62	0	−22	−6
Day 3 after chymopapain
SII and Ins	Right	1.32	−18	16	4
	Left	2.41*	14	14	4
Thalamus	Right	0.31	4	4	6
	Left	0.28	−6	2	2
Cingulate cortex		0.76	2	−20	−4
Day 9 after chymopapain
SII and Ins	Right	1.22	−14	14	4
	Left	1.64	12	10	2
Thalamus	Right	0.34	4	2	4
	Left	0.36	−4	2	2
Cingulate cortex		0.43	2	−22	−6
Day 14 after chymopapain
SII and Ins	Right	0.78	−10	14	4
	Left	1.38	14	10	4
Thalamus	Right	0.87	6	2	6
	Left	0.56	−6	4	2
Cingulate cortex		0.46	0	−24	−6

1 kg of force was applied to the back of the macaque in a block design during MR imaging.

SII, secondary somatosensory cortex; Ins, insular cortex.

Z values of peak voxels are shown. Stereotaxic coordinates according to Horsley-Clarke’s stereotaxic coordinates. * Peak voxels were considered significant (P <0.05) at Z score >1.96.