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. 2019 Oct 1;9(10):2170–2193.

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Concurrent loss of LKB1 and p53 in the mouse endometrium led to the development of invasive endometrial tumors. Genotyping of generated LKB1^fl/fl p53^fl/fl mice in mouse toes. The genotypes were confirmed by polymerase chain reaction using specific deigned primers (A). AdCre injection procedure: After laparotomy under general anesthesia, the left side of uterus was closed by suture ligation as shown in (B). Adcre (5 ul) was injected by puncturing the uterine wall with a 30 gauge needle. Gross pictures of the intact uterus at 12 weeks after injection. An endometrial tumor is located in the left side of uterus (C). Histopathology of normal uterus (top) and LKB1 p53-deficient endometrial carcinomas (bottom, D). Kaplan-Meier survival curves for LKB1^fl/fl, p53^fl/fl and LKB1^fl/fl p53^fl/fl mice of indicated genotypes as a function of days after Ade-cre administration (E). IHC results showed that expression of LKB1 and p53 was decreased in endometrial tumor tissues of LKB1^fl/fl p53^fl/fl (F).