Figure 8.
Metabolic effects of obesity and metformin on endometrial tumors in the LBKfl/flp53fl/fl mouse model. Metabolomic profiling indicated that obesity significantly increased energy metabolism and protein/lipid biosynthesis, as demonstrated by increases in glycolytic and oxidative phosphorylation intermediates, amino acids, peptides, nucleotides, fatty acids, and phospholipids in endometrial tumor tissues of obese compared with lean mice (Red = increased, Green = decreased, P < 0.05) (A). Metformin treatment decreased free fatty acids, phospholipids, lysolipids and sphingolipids in the obese- versus lean-endometrial tumors (B), and increased protein degradation markers (C), indicative of reversal of obesity-driven upregulation of lipid and protein biosynthesis. Schematic of the effects of obesity and metformin in obese versus lean endometrial tumors (A and C).