Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanism of HER2 targeted drugs and EGFR family in breast cancer. Trastuzumab, pertuzumab and TDM-1 bind to the juxtamembrane domain of HER2. Lapatinib is reversible TKI of HER1 and HER2, while neratinib and pyrotinib are irreversible HER 1, 2 and 4 inhibitors. These drugs inhibit downstream signals of EGFR family, especially PI3K/Akt and MAPK pathway, improving proliferation, survival, migration, angiogenesis, drug resistance and suppressing apoptosis of cancer cells.
