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Activation of NK cells by the NKG2D/NKG2DL pathway. A. The balance of signals mediated by activation and inhibition of specific receptors determines the activation of NK cells. B. Tumor cells overexpress NKG2DLs that can be recognized by the NKG2D receptor, which function as a “master switch” and elicits NKG2D-mediated cytotoxicity. This figure was created using Adobe Illustrator.
