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The dual functions of NKG2D/NKG2DL in tumor immunity. A. Induction of NKG2DLs on tumor cells induces immune surveillance via binding to NKG2D receptors expressed on NK and T cells. B. Failure to kill tumor cells due to the shedding of NKG2DLs by metalloproteinases. TGF-β allows immune surveillance escape by inhibiting T and NK cell function. NKG2D, Natural killer group 2, member D; sNKG2DLs, soluble NKG2D ligands. This figure was created using Adobe Illustrator.
