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. 2019 Oct 1;9(10):2120–2139.

Figure 6.

Figure 6

Effect of S1P and S2P inhibitors on GSK343-induced SREBP2 processing. A. HepG2 and PLC5 cells were pretreated with AEBSF for 1 h and then exposed to GSK343 for 6 h. The whole cell lysates were analyzed by Western blotting. B. HepG2 and PLC5 cells were pretreated with PF-429242 or Nelfinavir for 1 h and then exposed to GSK343 for 6 h. The whole cell lysates were analyzed by Western blotting. C. HepG2 and PLC5 cells were treated with GSK343 with or without 10 μM PF-429242 for 72 h. Cell viability was analyzed by MTS assay.