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Effect of AKT, mTOR, and ER stress inhibitors on GSK343-induced SREBP2 activation. HepG2 and PLC5 cells were pretreated with LY-294002 (A), rapamycin (B), ISRIB (C), or GSK-2606414 (D) for 1 h and then exposed to GSK343 for 6 h. The whole cell lysates were analyzed by western blotting.
