Figure 9.

Prediction of GSK343 targets by structural similarity comparison. A. Three sub-structures (highlighted in different colors) were used to compare with other compounds to identify similar compounds to GSK343. Drug structures and their accessing numbers in the Binding Database (https://www.bindingdb.org/) were shown. The corresponding targets and the activity (IC50 or Ki values) of each compound were indicated. B. Target prediction was performed using an online tool, HitPick (http://mips.helmholtz-muenchen.de/hitpick/).