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. 2019 Oct 31;10:2579. doi: 10.3389/fimmu.2019.02579

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Copyright © 2019 Chaves-Pozo, Valero, Lozano, Rodríguez-Cerezo, Miao, Campo, Esteban and Cuesta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nodavirus (NNV) infection up-regulated the transcription of granzymes. The gene expression of gzma (A), gzmb (B), and gzmm (C) was determined by qPCR in the brain or head-kidney (HK) from gilthead seabream or European sea bass specimens at 1, 7, or 15 days-post-infection (dpi) with nodavirus (NNV). Data represent the mean ± SEM (n = 5) of the fold change respect to the values found in controls. Asterisks denote significant differences between NNV-infected and controls (t-Student, P ≤ 0.05).