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. 2019 Nov 6;9:16130. doi: 10.1038/s41598-019-52513-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ferroptotic pathway mRNA enrichment analysis based on the KEGG database. Differentially expressed mRNA were labeled into the map of ferroptosis pathway obtained from KEGG database with official permission and guidance^57–59. (A) Differentially expressed mRNA between the control and 10 µM dexamethasone treatment groups in the KEGG ferroptotic pathway based on 2 biological replicates. The downregulated genes are labelled with green, and the upregulated genes are labelled with red. (B) Differentially expressed mRNA between the 10 µM dexamethasone and 10 µM dexamethasone + 100 µg EPC-EV treatment groups in the KEGG ferroptotic pathway based on 2 biological replicates. The downregulated genes are labelled with green, and the upregulated genes are labelled with red.