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. 2019 Nov 6;9:16130. doi: 10.1038/s41598-019-52513-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of the functional role of EPC-EVs in the alleviation of SIOP. In the present study, high-dose dexamethasone activated the ferroptotic signalling pathway in mouse osteoblasts. The administration of EPC-EVs triggers alterations in DNA and the transcriptome, inhibiting the activation of the ferroptotic pathway following 10 µM dexamethasone treatment in osteoblasts. The intramuscular delivery of high-dose dexamethasone triggered SIOP in mice, and EPC-EVs alleviated the pathogenesis of SIOP, with improved bone structure parameters.