Fig. 2.

Interpretation of factors obtained from WON-PARAFAC. a Assessment of tissue types enrichment; gene set enrichment and association to drug responses for cell-factors. b–d (b) Gene factor (gene-factor) matrix, c cell line factor (cell-factor) matrix, and d data type factor (DT-factor) matrix visualized in heatmaps, for the selected factors and their top associated genes, cell lines, and data types, respectively. Factor loading is indicated by color gradient, which is the strength of the association. e–g Associations between the selected factors and tissue types (e), enriched pathways (f), and compounds (g) in heatmaps where their color gradient represents the significance of association in Z-scores, signed Z-scores, and coefficients from EN, respectively. The sign in Z-score indicates up or down-regulation of pathways, and sign in EN coefficients indicates sensitivity (negative) or resistance (positive) to compounds