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. 2019 Nov 6;10:5034. doi: 10.1038/s41467-019-13027-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Network-based combined interpretation of factors that explain drug responses. a Top factors (square nodes) explaining the response to Afatinib (BIBW2992; pink node) with their associated tissue types (green nodes) and functions (dark yellow, blue and blue-green nodes) in a network. Listed in the corresponding node are the top genes from each factor indicating the factor. The types of node and edges are denoted by colors indicated in the figure. The nodes mentioned in the text are highlighted. b Afatinib response of cell lines by tissue types highlighted in a. Two sensitive head and neck cancer cell lines (CAL-27 and HSC-3) are indicated. Standard notations are used for elements of the boxplot (i.e. upper/lower hinges: 75th/25th percentiles; inner-segment: median; and upper/lower whiskers: extension of the hinges to the largest/smallest value at most 1.5 times of interquartile range). c Top factors that explain the response to TOP1 inhibitors, SN-38 (Irinothecan) and Camptothecin represented in a network (format as in a). d Camptothecin (top panel) and SN-38 (Irinotecan; bottom panel) response of cell lines by tissue types highlighted in c. Color of nodes indicates higher loading in sensitive factors (green) and resistance factors (red) for each cell line. Standard notations are used for elements of the boxplots