Table 2.
Risks for in situ and invasive cervical cancers in families of any in situ cancer, and risk for any in situ cancers in families of in situ and invasive cervical cancers.
| Cancer site family member | RR for in situ cervical cancer when family member had in situ cancer | RR for in situ cancer when family member had in situ cervical cancer | RR for cervical cancer when family member had in situ cancer | RR for in situ cancer when family member had cervical cancer | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | RR | 95%CI | Cases | RR | 95%CI | Cases | RR | 95%CI | Cases | RR | 95%CI | |
| Other female genital | 458 | 1.59 | 1.45–1.74 | 347 | 1.79 | 1.60–2.01 | 26 | 1.22 | 0.83–1.80 | 51 | 1.42 | 1.08–1.87 |
| Skin, squamous cell | 5966 | 0.93 | 0.91–0.96 | 1645 | 1.03 | 0.98–1.08 | 427 | 0.86 | 0.78–0.94 | 378 | 0.99 | 0.90–1.10 |
| Male | NR | 806 | 1.04 | 0.97–1.12 | NR | 198 | 1.06 | 0.92–1.21 | ||||
| Female | As above | 839 | 1.01 | 0.95–1.09 | As above | 180 | 0.93 | 0.81–1.08 | ||||
| Upper aerodigestive tract | 243 | 1.08 | 0.96–1.23 | 86 | 1.26 | 1.01–1.57 | 22 | 1.24 | 0.82–1.89 | 24 | 1.57 | 1.05–2.36 |
| Male | NR | 51 | 1.15 | 0.87–1.53 | NR | 13 | 1.30 | 0.75–2.26 | ||||
| Female | As above | 35 | 1.44 | 1.02–2.04 | As above | 11 | 2.06 | 1.13–3.75 | ||||
| Other male genital | 117 | 1.27 | 1.06–1.52 | 56 | 1.00 | 0.76–1.31 | 9 | 1.33 | 0.69–2.55 | 16 | 1.57 | 0.96–2.57 |
| Colorectum | 2223 | 0.97 | 0.93–1.02 | 819 | 0.99 | 0.92–1.06 | 181 | 1.03 | 0.89–1.19 | 185 | 0.98 | 0.85–1.13 |
| Male | NR | 476 | 1.02 | 0.93–1.12 | NR | 113 | 1.05 | 0.87–1.26 | ||||
| Female | As above | 343 | 0.95 | 0.85–1.06 | As above | 72 | 0.89 | 0.70–1.12 | ||||
| Melanoma | 1850 | 0.98 | 0.94–1.03 | 1283 | 1.09 | 1.03–1.15 | 122 | 0.93 | 0.78–1.11 | 219 | 0.97 | 0.85–1.11 |
| Male | NR | 541 | 1.02 | 0.93–1.11 | NR | 112 | 1.04 | 0.86–1.25 | ||||
| Female | As above | 742 | 1.14 | 1.06–1.23 | As above | 107 | 0.90 | 0.74–1.09 | ||||
| Non-Hodgkin lymphoma | 144 | 1.24 | 1.05–1.46 | 65 | 1.36 | 1.06–1.75 | 12 | 1.34 | 0.76–2.36 | 11 | 1.09 | 0.60–1.97 |
| Male | NR | 40 | 1.47 | 1.06–2.03 | NR | 5 | 0.85 | 0.35–2.05 | ||||
| Female | As above | 25 | 1.22 | 0.81–1.83 | As above | 6 | 1.42 | 0.64–3.19 | ||||
| All (including cervix) | 33607 | 1.35 | 1.33–1.37 | 26966 | 1.52 | 1.50–1.54 | 2090 | 1.12 | 1.07–1.18 | 4089 | 1.31 | 1.27–1.36 |
| Male | NR | 2474 | 1.05 | 1.01–1.09 | NR | 558 | 1.06 | 0.97–1.15 | ||||
| Female | As above | 24492 | 1.58 | 1.56–1.60 | As above | 3531 | 1.36 | 1.31–1.40 | ||||
RR = relative risk, 95%CI = 95% confidence interval, bold font indicates that the lower limit of 95%CI does not include 1.00.