Table 4.

Risks for in situ and invasive skin squamous cell cancers in families of any in situ cancer, and risk for any in situ cancers in families of in situ and invasive skin squamous cell cancers.

Cancer site family member	RR for in situ skin squamous cell cancer when family member had in situ cancer			RR for in situ cancer when family member had in situ skin squamous cell cancer			RR for skin squamous cell cancer when family member had in situ cancer			RR for in situ cancer when family member had skin squamous cell cancer
	Cases	RR	95%CI	Cases	RR	95%CI	Cases	RR	95%CI	Cases	RR	95%CI
Cervix	1645	1.03	0.98–1.08	5966	0.93	0.91–0.96	1106	1.13	1.06–1.20	4201	0.98	0.95–1.02
Male	806	1.04	0.97–1.12	NR			633	1.15	1.06–1.24	NR
Female	839	1.01	0.95–1.09	As above			473	1.10	1.00–1.21	As above
Other female genital	73	1.38	1.09–1.73	163	1.25	1.06–1.46	46	1.42	1.06–1.90	102	1.13	0.93–1.38
Male	45	1.69	1.26–2.26	NR			28	1.51	1.04–2.19	NR
Female	28	1.06	0.73–1.53	As above			18	1.34	0.84–2.13	As above
Upper aerodigestive tract	74	1.48	1.18–1.86	72	1.33	1.05–1.69	44	1.49	1.11–2.00	55	1.44	1.10–1.89
Male	35	1.45	1.04–2.01	46	1.31	0.98–1.77	26	1.56	1.06–2.29	24	0.96	0.64–1.45
Female	39	1.52	1.11–2.08	26	1.35	0.91–2.00	18	1.40	0.88–2.23	31	2.33	1.62–3.35
Other male genital	25	1.44	0.97–2.13	37	0.97	0.70–1.35	14	1.35	0.80–2.29	26	1.00	0.68–1.48
Male	16	1.93	1.18–3.15	As above			9	1.57	0.82–3.01	As above
Female	9	0.99	0.52–1.90	NR			5	1.10	0.46–2.64	NR
Colorectum	482	1.03	0.94–1.13	651	0.93	0.86–1.00	296	1.06	0.94–1.18	427	0.86	0.78–0.95
Male	227	0.98	0.86–1.11	352	0.87	0.78–0.97	172	1.07	0.92–1.25	249	0.88	0.77–0.99
Female	255	1.08	0.95–1.22	299	1.00	0.89–1.13	124	1.04	0.87–1.24	178	0.84	0.72–0.97
Melanoma	517	1.63	1.49–1.78	1371	1.59	1.51–1.68	296	1.54	1.38–1.73	896	1.50	1.40–1.60
Male	250	1.59	1.40–1.80	651	1.56	1.44–1.69	159	1.45	1.24–1.70	442	1.53	1.39–1.68
Female	267	1.67	1.48–1.88	720	1.62	1.50–1.75	137	1.67	1.41–1.97	454	1.47	1.34–1.62
Non-Hodgkin lymphoma	28	1.17	0.81–1.70	40	1.09	0.79–1.50	19	1.33	0.85–2.09	25	0.97	0.65–1.44
Male	12	1.03	0.59–1.82	26	1.20	0.81–1.79	11	1.36	0.75–2.45	13	0.85	0.49–1.48
Female	16	1.31	0.80–2.14	14	0.93	0.54–1.58	8	1.30	0.65–2.61	12	1.14	0.64–2.03
All (including SCCa)	6424	1.50	1.46–1.55	13348	1.18	1.16–1.20	3677	1.41	1.36–1.46	9009	1.17	1.14–1.19
Male	3180	1.51	1.45–1.57	3099	1.56	1.51–1.62	2121	1.43	1.36–1.50	2060	1.47	1.41–1.54
Female	3244	1.50	1.44–1.56	10249	1.10	1.08–1.12	1556	1.39	1.32–1.47	6949	1.10	1.07–1.12

SCC^a = skin squamous cell cancer.

RR = relative risk, 95%CI = 95% confidence interval, bold font indicates that the lower limit of 95%CI does not include 1.00.