Table 2.

Differences in residue interaction network (RIN) analysis of SEPHS2 during MD simulations in water at neutral and acidic pH.

Neutral pH	0 ns	Residue interaction network				10 ns
		2 ns	4 ns	6 ns	8 ns
	Ile 322	Lys 252	His 325	Phe 140	Phe 140	Phe 139
	Phe 199	Phe 199	Leu 159	Tyr 163	Glu 369	Phe 140
			Lys 252	Phe 199	Ile 322	Phe 199
			Phe 199		Lys 252	Tyr 163
			Tyr 163		Phe 199
Acidic pH		Phe 320	Phe 199	Phe 199	Phe 199	Phe 199
		Glu 283	His 325	Phe 320	Phe 140	Val 158
		Lys 190	Met 295	Phe 140	Phe 320	Asn 157
			Phe 140
			Phe 360