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. 2019 Nov 6;9:16137. doi: 10.1038/s41598-019-52411-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression analysis of Htt transcripts in five brain regions using the custom-made 14-plex QuantiGene assay. The expression of intronic Htt transcripts in 2 month old mice are presented relative to that for housekeeping genes. (a–e) The Httexon1 transcript is present in all zQ175 brain regions. (f–j) The level of the Htt-FL transcript is significantly decreased in the striatum, cortex and hippocampus as measured by the E50-53 and all 3′UTR probe sets. Data were from n = 4/genotype with two technical replicates. Statistical analysis was by multiple t-test with Benjamini-Hochberg with an alpha of 0.05, *p < 0.05, **p < 0.01, ***p < 0.001. Tissue lysate dilutions were 1:3 for striatum, hippocampus and brain stem, 1:4 for cortex and cerebellum.