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. 2019 Oct 31;6:247. doi: 10.3389/fmed.2019.00247

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Copyright © 2019 Blank, Schenker, Dawson, Beldi, Zlobec and Lugli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative images of perimetastatic and intrametastatic budding on H&E and Pan-CK staining. Examples of tumor buds are indicated with an asterisk.