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. 2019 Oct 31;13:252. doi: 10.3389/fnbeh.2019.00252

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Copyright © 2019 Sinclair, Klump and Sisk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pharmacological inactivation of mPFC enhances 1 h PF intake in BERs and in BEPs. Cohen’s d values in (a) represent the comparison of PF intake at saline to PF intake at 30 ng muscimol, calculated within each phenotype individually. Percent change in 1 h PF intake (b) was calculated relative to each rat’s individual PF intake value at saline. Group means in (b) represent ANCOVA-adjusted means, with each rat’s PF intake at saline as the covariate. Chow intake, after 1 h (c) and 4 h (d) of exposure, was unaffected by inactivation of the mPFC. Error bars in (a–d) represent 1 SEM. and doses of muscimol represent amount infused (in ng) into each hemisphere. Bilateral cannula placements along the rostro-caudal extent of the mPFC are shown in (e) and a representative image of cannula tracks within the mPFC is shown in (f). ME, main effect; ^#p < 0.05, main effect of drug.