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. 2019 Nov 6;10:5046. doi: 10.1038/s41467-019-13017-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — IL-27R signaling is needed for HSPC differentiation. a Scheme of ex vivo colony-formation experiment. b Lin⁻ HSPCs were isolated from BM of Apoe^−/−Il27ra^+/− (n = 6) or Apoe^−/−Il27ra^−/− (n = 6) mice infused with Ang II and plated in M3434 media under myeloid conditions. Granulocyte–monocyte (GM) colony formation was accessed on day 6. c Scheme of in vitro colony-formation experiment. d Lin⁻ HSPCs were isolated from BM of Apoe^−/− (n = 4) mice and plated in M3434 media under myeloid conditions in the presence of Ang II, recIL-27, Ruxolitinib, or their combination. GM colony formation was accessed on day 6. Data are mean ± SEM from three independent experiments. **p < 0.01, ***p < 0.005, unpaired Student’s t-test (two-tailed)