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Pharmacokinetic parameters for hemizygotic Tg276 hFcRn transgenic mice
| AUCinf. (μg days/mL) | Clearance (mL/day) | β-phase T1/2 (h) | Vss (mL/kg) | |
|---|---|---|---|---|
| wt-IgG1 | 30.0 ± 1.6 | 0.66 ± 0.17 | 49.6 ± 13.4 | 1.50 ± 0.15 |
| DHS-IgG1 | 157.9 ± 3.4 | 0.11 ± 0.01 | 290.9 ± 25.6 | 0.59 ± 0.11 |
| YTE-IgG1 | 96.9 ± 3.3 | 0.24 ± 0.03 | 148.4 ± 36.8 | 0.72 ± 0.14 |
| LS-IgG1 | 84.4 ± 2.0 | 0.21 ± 0.03 | 92.9 ± 6.1 | 0.60 ± 0.06 |
Data are presented as mean ± standard deviation (n = 11)
