Figure 2.

Blockade of VISTA or PD-1 significantly inhibit kidney tumor growth. (A and B) Representative figures and summarized data of infiltrated T cells in tumors of patients in VISTA^hi and VISTA^low groups. *P < 0.05, **P < 0.01. (C and D) Representative figures and summarized data displaying granzyme B, perforin, TNFα and IFNγ expression in CD8⁺ T cells in tumors. *P < 0.05, **P < 0.01. (E) Mean tumor volume and tumor weight of subcutaneous RENCA inoculation in mice treated with control antibodies, anti-VISTA, anti-PD-1, or anti-VISTA plus anti-PD-1 (n = 6). *P < 0.05, **P < 0.01