Table 1.

Eye signs and symptoms in siblings affected by IU and/or MS

Patient	Age of onset of ocular symptoms (y/o)	Ocular symptoms	BCVA at onset	Ophthalmologic findings	Diagnosis	Last BCVA	Treatment
M-XY EMU003	12	Asymptomatic (evaluation after family history)	OD 20/20 OS 20/20	OD: vascular sheathing, vitreoussnowballs. OS: no inflammatory involvement.	Intermediate uveitis	OD 20/20 OS 20/20	Observation
M-XY M004	24	Asymptomatic (evaluation after family history)	OD 20/40 OS 20/50	OD posterior subcapsular cataract > OS OS: vitritis, snowballs and snowbanks.	Intermediate uveitis	OD 20/30 OS 20/50	Topic and injected periocular steroids. Systemic corticosteroids, prednisolone, and systemic immunosuppressant, methotrexate
F-XX EMU005	11	FloatersDecreased vision OD	OD 20/40 OS 20/15	OD: retinal detachment OS: vitritis, peripheral retinal detachment, dense snowballs.	Intermediate uveitis	OD NLP OS 20/20	Topic and injected periocular steroids. Systemic corticosteroids, prednisolone, and systemic immunosuppressant, methotrexate (higher doses).
F-XX EMU002	10	Decreased vision OD	OD 20/800 OS 20/20	OD: retinal detachment OS: vitritis, snowballs, posterior subcapsular cataract.	Intermediate uveitis	OD NLP OS 20/30	Topic and injected periocular steroids. Systemic corticosteroids, prednisolone, and systemic immunosuppressant, methotrexate (higher doses).

BCVA best corrected visual acuity, OD right eye, OS left eye, NLP no light perception