Table 3.
Parametric and non-parametric estimated LOD scores in regions with suggestive and nominal genetic linkage with the list of genes contained in minimal critical regions defined by the 1-LOD score criterion
| Chr | Position | 1-LOD score lower | 1-LOD score upper | LODMAX | NPL SPAIR | NPL SALL | Genes |
|---|---|---|---|---|---|---|---|
| 1 | 145112414 | 0.905867 | 1.470478 | 1.806331 | 3.464102 | 3.684484 | HIST2H3PS2, FAM72C, PPIAL4E, NBPF15, PPIAL4F, SRGAP2B, FAM72D, PPIAL4D, NBPF20 |
| 2 | 130951584 | 0.946075 | 1.377104 | 1.805566 | 3.464102 | 3.684484 | ARHGEF4, AC009477.2, FAM168B, PLEKHB2, POTEE, WTH3DI, MZT2A, TUBA3D, CCDC74A, ANKRD30BL, STAM2, FMNL2, PRPF40A, ARL6IP6 |
| 6 | 57467303 | 1.1247 | 1.4644 | 1.7774 | RCC2P7, DST, AL512422.2, RNU6-626P, BEND6, OSTCP6, FTH1P15, KIAA1586, ZNF451, BAG2, RAB23, PRIM2, MIR548U, GUSBP4, POM121L14P, LINC00680, GAPDHP15, RBBP4P4 | ||
| 7 | 128315882 | 1.230381 | 0.234805 | 1.805566 | 3.464102 | 3.684483 | STEAP4, ZNF804B, TEX47, STEAP1, STEAP2, CFAP69, FAM237B, GTPBP10, CLDN12, CDK14, FZD1, MTERF1, AKAP9, CYP51A1, LRRD1, KRIT1, ANKIB1, GATAD1, ERVW-1, PEX1, RBM48, FAM133B, CDK6, SAMD9, SAMD9L, HEPACAM2, VPS50, CALCR, GNGT1, TFPI2, GNG11, BET1, COL1A2, CASD1, SGCE, PEG10, PPP1R9A, AC002429.2, PON1, PON3, PON2, ASB4, PDK4, DYNC1I1, SLC25A13, SEM1, DLX6, DLX5, SDHAF3, TAC1, ASNS, OCM2, LMTK2, BHLHA15, TECPR1, BRI3, BAIAP2L1, NPTX2, TMEM130, TRRAP, SMURF1, KPNA7, ARPC1A, ARPC1B, PDAP1, BUD31, PTCD1, ATP5J2-PTCD1, CPSF4, ATP5J2, ZNF789, ZNF394, ZKSCAN5, FAM200A, ZNF655, TMEM225B, ZSCAN25, CYP3A5, CYP3A7-CYP3A51P, CYP3A7, CYP3A4, CYP3A43, OR2AE1, TRIM4, GJC3, AZGP1, ZKSCAN1, ZSCAN21, ZNF3, COPS6, MCM7, AP4M1, TAF6, CNPY4, MBLAC1, LAMTOR4, C7orf43, GAL3ST4, GPC2, STAG3, GATS, PVRIG, SPDYE3, PILRB, PILRA, ZCWPW1, MEPCE, PPP1R35, C7orf61, TSC22D4, NYAP1, AGFG2, SAP25, LRCH4, FBXO24, PCOLCE, MOSPD3, TFR2, ACTL6B, GNB2, GIGYF1, POP7, EPO, ZAN, EPHB4, SLC12A9, TRIP6, SRRT, UFSP1, ACHE, MUC3A, MUC12, MUC17, TRIM56, SERPINE1, AP1S1, VGF, NAT16, MOGAT3, PLOD3, ZNHIT1, CLDN15, FIS1, IFT22, COL26A1, MYL10, CUX1, SH2B2, SPDYE6, PRKRIP1, ORAI2, ALKBH4, LRWD1, POLR2J, RASA4B, POLR2J3, SPDYE2, RASA4, UPK3BL1, POLR2J2, SPDYE2B, POLR2J2, FAM185A, FBXL13, LRRC17, NFE4, ARMC10, NAPEPLD, PMPCB, DNAJC2, PSMC2, SLC26A5, RELN, ORC5, LHFPL3, KMT2E, SRPK2, PUS7, RINT1, EFCAB10, ATXN7L1, CDHR3, SYPL1, NAMPT, CCDC71L, PIK3CG, PRKAR2B, HBP1, COG5, GPR22, DUS4L, BCAP29, SLC26A4, CBLL1, SLC26A3, DLD, LAMB1, LAMB4, NRCAM, PNPLA8, THAP5, DNAJB9, IMMP2L, LRRN3, DOCK4, ZNF277, IFRD1, LSMEM1, TMEM168, BMT2, GPR85, SMIM30, PPP1R3A, FOXP2, MDFIC, TFEC, TES, CAV2, CAV1, MET, CAPZA2, ST7, WNT2, ASZ1, CFTR, CTTNBP2, LSM8, ANKRD7, KCND2, TSPAN12, ING3, CPED1, WNT16, FAM3C, PTPRZ1, GCC1, KLF14, CCDC136, PARP12, TSPAN33, TBXAS1, LRGUK, MKRN1, BPGM, IRF5, SND1, LRRC4, CPA5, TMEM209, ZNF800, BRAF, STRA8, GRM8, C7orf77, CLEC2L, FAM71F2, FMC1, OPN1SW, CLEC5A, AC011005.1, CNOT4, PAX4, RAB19, SMO, FSCN3, ZC3HAV1L, ZC3HAV1, TNPO3, WDR91, DENND2A, ATP6V0A4, SVOPL, ADCK2, KCP, C7orf55-LUC7L2, GPR37, AKR1B15, POT1, AGBL3, OR9A4, TAS2R38, CEP41, TMEM213, AKR1B1, PLXNA4, TAS2R5, WEE2, C7orf49, MKLN1, AKR1B10, SMKR1, LUC7L2, ATP6V1F, FLNC, TMEM140, HIPK2, MEST, ARF5, SLC37A3, NDUFB2, SSU72P8, FAM71F1, CALD1, KDM7A, KLRG2, SLC35B4, SSBP1, CPA2, UBN2, PRSS37, ZC3HC1, AKR1D1, KIAA1147, NRF1, UBE2H, COPG2, TAS2R4, METTL2B, CPA1, HILPDA, KLHDC10, STRIP2, TRIM24, TAS2R3, KIAA1549, CALU, EXOC4, CHCHD3, MGAM, PODXL, TSGA13, TMEM178B, MRPS33, CREB3L2, AGK, CPA4, TTC26, IMPDH1, SSMEM1, LEP, NUP205, RBM28, AHCYL2, C7orf73, SLC13A4, FAM180A, LUZP6, MTPN, CHRM2, PTN, DGKI, PRRT4 |
| 9 | 68433567 | 0.802898 | 1.312274 | 1.557544 | 2.697369 | 2.819446 | PGM5 |
| 10 | 46999151S | 1.355892 | 1.507883 | 1.805282 | 3.462968 | 3.683198 | AKR1C2, AKR1C3, AKR1C4, UCN3, TUBAL3, NET1, PTPN20 |
| 11 | 104768909 | 1.2454 | 0.6977 | 1.8056 | MUC6, MUC5AC, C11orf88, BTG4, CASP1, DCUN1D5, MMP10, MMP7, POU2AF1, CASP5, FDX1, SLN, GUCY1A2, ARHGAP20, RDX, NPAT, ATM, ELMOD1, DYNC2H1, RAB39A, GRIA4, CUL5, ALKBH8, PDGFD, DDI1, LAYN, COLCA2, C11orf53, EXPH5, KBTBD3, MSANTD4, ZC3H12C, ANGPTL5, CWF19L2, AASDHPPT, CASP4, DDX10, SLC35F2, C11orf87, KDELC2, CARD17, MMP13, CARD18, MMP12, C11orf65, ACAT1, TMEM123, BIRC2, CARD16, YAP1, CEP126, MMP3, MMP8, C11orf70, MMP1, MMP27, MMP20, PGR, TMEM133, BIRC3, TRPC6, ARHGAP42 | ||
| 13 | 19239331 | 1.708426 | 1.374161 | 1.710696 | 3.092112 | 3.264238 | TUBA3C |
| 14 | 90730265 | 0.535392 | 1.433905 | 1.805566 | 3.464102 | 3.684484 | OR4N2, OR4K5, OR4K1, OR4K15, OR4K14, OR4K13, OR4L1, OR4K17, OR4N5, OR11G2, OR11H6, OR11H4, TTC5, CCNB1IP1, PARP2, TEP1, KLHL33, OSGEP, APEX1, TMEM55B, PNP, C14orf177, ATG2B, DIO3, SERPINA5, AL049839.2, DDX24, EVL, OTUB2, CDC42BPB, RPS6KA5, SYNE3, SLC24A4, ANKRD9, TECPR2, WDR20, SERPINA9, BCL11B, TMEM251, RIN3, TNFAIP2, NRDE2, WDR25, NDUFB1, CCDC85C, TTC7B, KCNK13, DICER1, EFCAB11, DLK1, BTBD7, DEGS2, SERPINA3, CCDC197, ASB2, VRK1, ZNF839, CCNK, TCL1A, TCL1B, MARK3, SETD3, CINP, DYNC1H1, SERPINA12, SERPINA11, IFI27L1, MOAP1, WARS, ITPK1, PAPOLA, SERPINA4, SLC25A47, YY1, PSMC1, EML1, AL161669.4, TRAF3, HHIPL1, AMN, GSKIP, CLMN, GSC, SLC25A29, RCOR1, TUNAR, HSP90AA1, CHGA, EIF5, C14orf132, UBR7, LGMN, CPSF2, C14orf159, AK7, GOLGA5, CALM1, BDKRB1, GLRX5, EXOC3L4, BDKRB2, MOK, CYP46A1, TDP1, PPP2R5C, BEGAIN, SERPINA1, IFI27L2, FAM181A, PRIMA1, UNC79, IFI27, PPP4R4, GON7, RTL1, SERPINA10, COX8C, CATSPERB, CCDC88C, SERPINA6, FBLN5, PPP4R3A, ATXN3, TRIP11, TC2N, GPR68, ASPG, RD3L, TMEM179, C14orf180, TDRD9, C14orf2, KIF26A |
| 15 | 101827759 | 1.276506 | 1.804787 | 1.805562 | 3.464085 | 3.684465 | GOLGA8G, GOLGA6L7P, APBA2, ALDH1A3, LRRK1, OR4F4, OR4F6, TARSL2, CHSY1, SELENOS, PCSK6, OR4F15, TM2D3, SNRPA1 |