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. 2019 Oct 31;10:1145. doi: 10.3389/fneur.2019.01145

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Copyright © 2019 Fleury-Teixeira, Caixeta, Ramires da Silva, Brasil-Neto and Malcher-Lopes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Improvement of symptoms observed in the patients that underwent CE treatment for at least 6 months. Data was collected from the caretakers' monthly follow-up questionnaires. (A) Pooled data from all 15 patients in the following categories: attention deficit/hyperactivity disorder (ADHD, n = 15); behavioral disorders (BD, n = 15); motor deficits (MD, n = 12); autonomy deficits (AD, n = 15); communication and social interaction deficits (CSID, n = 15); cognitive deficits (CD, n = 15); sleep disorders (SD, n = 12); convulsive seizures (SZ, n = 5). (B) Subset including only the 10 non-epileptic patients that underwent CE treatment for at least 6 months. Attention deficit/hyperactivity disorder (ADHD, n = 10); behavioral disorders (BD, n = 10); motor deficits (MD, n = 7); autonomy deficits (AD, n = 10); communication and social interaction deficits (CSID, n = 10); cognitive deficits (CD, n = 10); sleep disorders (SD, n = 7). Red lines denote medians, blue boxes the interquartile range, black whiskers the minimum and maximum values. Note that all categories present improvements that range from modest to robust, in spite of a very short period of treatment with CE.