Table 1. Diabetes and Alzheimer's disease rodent models.
| Intervention | Pathophysiology |
|---|---|
| Non-AD mouse and rat models [50,51,52,53] | |
| Sterptozotocin | Increase pTau pathology and altered hippocampal synaptic plasticity |
| Diet | Mild effect on central nervous system |
| Amylin dyshomeostasis | Vascular amylin oligomer deposition |
| Microhaemorrhages | |
| Brain inflammation | |
| Brain atrophy | |
| Microglia activation | |
| Parenchymal amylin plaques | |
| Impaired synthesis of neurotransmitters | |
| Leptin deficiency | Increased amyloid-β generation |
| Mouse and rat models of AD [50-53] | |
| Sterptozotocin | Exacerbated brain amyloidosis |
| Neuro-inflammation and injury | |
| Diet | Increased amyloid-β pathology |
| Leptin deficiency | Amyloid-β |
| Aneurisms | |
| Small strokes |
AD, Alzheimer's disease; pTau, phosphorylated tau.