. 2019 Nov 6;9:16098. doi: 10.1038/s41598-019-52658-9

Table 3.

Left and right frontal cortex vs. physiologic and metabolic parameters in each group of SHR.

LEFT			RIGHT
Correlation	r	p	Correlation	r	p
CONTROL
			MB CysAP vs WB	+0.836	0.009
No correlations			MB AlaAP vs GLU	+0.801	0.01
			MB GluAP vs NO Pl	+0.773	0.02
CAPTOPRIL
MB GluAP vs WB	+0.917	0.001	MB CysAP vs Protur	+0.946	0.0003
MB GluAP vs HDL	+0.796	0.01	Sol AlaAP vs NO Ur	+0.849	0.007
MB GluAP vs WI	+0.904	0.002	Sol GluAP vs NO Ur	+0.781	0.02
MB AlaAP vs DIU	+0.859	0.006	*Sol GluAP vs WB*	−*0.792*	*0.01*
Sol CysAP vs Creat	+0.781	0.02	*Sol CysAP vs GLU*	−*0.824*	*0.01*
*MB AlaAP vs Creat*	−*0.778*	*0.02*	*Sol GluAP vs GLU*	−*0.816*	*0.01*
*MB GluAP vs NO Ur*	−*0.911*	*0.001*	*Sol AlaAP vs WB*	−*0.758*	*0.02*
PROPRANOLOL
MB GluAP vs TCH	+0.830	0.01	No correlations
MB GluAP vs Creat	+0.862	0.005
L−NAME
MB AlaAP vs DIU	+0.912	0.001	Sol AlaAP vs TCH	+0.781	0.02
MB GluAP vs GLU	+0.896	0.002	Sol AlaAP vs LDL	+0.973	<0.0001
			*Sol CysAP vs WI*	−*0.892*	*0.002*
			*Sol GluAP vs WI*	−*0.879*	*0.004*
			*MB GluAP vs WI*	−*0.788*	*0.02*
			*Sol GluAP vs HDL*	−*0.757*	*0.02*
			*Sol AlaAP vs HDL/LDL*	−*0.826*	*0.01*
			*Sol GluAP vs HDL/LDL*	−*0.793*	*0.02*

Significant correlations between soluble (Sol) and membrane-bound (MB) aminopeptidase activities of the left and right frontal cortex with the different physiologic parameters and metabolic factors measured in plasma and urine in SHR, considering each of the four drug treatment groups independently. Pearson’s correlation coefficients (r) and p values are indicated. Negative correlations highlighted in italics. WI, water intake; DIU, diuresis; WB, water balance; TCH, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; GLU, glucose; NO Pl, nitric oxide in plasma; NO Ur, nitric oxide in urine; Protur, proteinuria; Creat, creatinine.