Table 1.

Lesion-specific sensitivity for the detection of 33 lesions among 20 patient datasets. The estimated sensitivity and confidence intervals are based on GEEs that account for the repeated interpretations of the patient datasets by either 10 readers or 5 performance-matched pseudo-readers derived from the fully crossed study design. The range presented is for the individual reader or pseudo-reader performances.

	Fully Crossed Design (10 readers)		Performance Matched Pseudo-Readers (5 pseudo-readers)
Noise Reduction Method	Sensitivity (95% GEE CI)	Range	Sensitivity (95% GEE CI)	Range
A	72.1 (67.3 to 77.0)	57.6 to 81.8	72.1 (65.3 to 79.0)	66.7 to 78.8
B	61.5 (56.3 to 66.8)	45.5 to 75.8	60.0 (52.5 to 67.5)	51.5 to 69.7
C	58.2 (52.9 to 63.5)	45.5 to 72.7	58.2 (50.7 to 65.7)	48.5 to 72.7