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. Author manuscript; available in PMC: 2020 Dec 1.

Published in final edited form as: Neurobiol Dis. 2019 Jul 23;132:104540. doi: 10.1016/j.nbd.2019.104540

Table 6.

Hippocampal dissection negative binomial regression models using TrkB as a predictor of entorhinal cortex and hippocampal CA1 AD pathology.

Entorhinal Cortex
						Coefficient	SE	p-value

					Outcome = NPs

					*TrkB*	−0.22	0.21	0.29
					APOE ε4	0.50	1.34	0.71
					APOE ε4 x TrkB	0.05	0.37	0.89

					Outcome = DPs

					*TrkB*	−0.26	0.21	0.22
					APOE ε4	−0.12	1.37	0.93
					APOE ε4 x TrkB	0.05	0.37	0.88

					Outcome = NFTs

					*TrkB*	−0.26	0.10	0.04^*
					APOE ε4	0.45	0.68	0.51
					APOE ε4 x TrkB	0.00	0.19	0.99

Hippocampal CA1
						Coefficient	SE	p-value

					Outcome = NPs

					*TrkB*	−0.58	0.19	0.006^*
					APOE ε4	−0.88	1.38	0.52
					APOE ε4 x TrkB	0.48	0.39	0.22

					Outcome = DPs

					*TrkB*	−0.31	0.27	0.26
					APOE ε4	1.68	1.56	0.28
					APOE ε4 x TrkB	0.08	0.42	0.85

					Outcome = NFTs

					*TrkB*	−0.26	0.12	0.08
					APOE ε4	0.98	0.81	0.22
					APOE ε4 x TrkB	−0.28	0.22	0.21

Models included age at death, gender, and APOE ε4 carrier status. SE = standard error.

^*

= significant.