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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Neurobiol Dis. 2019 Jul 24;132:104543. doi: 10.1016/j.nbd.2019.104543

Figure 3. Transient cellular behavior of tau.

Figure 3.

A, Physiological situation: Coming off the ribosome, tau is soluble, unfolded and monomeric. Upon binding to MTs, tau adopts a different fold, but almost immediately becomes soluble again. Tau phosphorylation may contribute to regulating the transient tau-MT interaction. B, Pathological situation (pathological states are in red): perturbed cellular tau homeostasis is characterized by tau hyper-phosphorylation, lack of tau-MT interaction, disintegration of MTs and the formation of proteinaceous tau aggregates.