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. Author manuscript; available in PMC: 2020 Nov 5.
Published in final edited form as: Cell Metab. 2019 Sep 12;30(5):890–902.e8. doi: 10.1016/j.cmet.2019.08.012

Figure 1. Stressors trigger a rapid surge of circulating bioactive osteocalcin (Ocn) in rodents and humans.

Figure 1.

(A) Serum Ocn levels in 3-month-old WT mice after restraint or foot shocks. (B-E) Serum Ocn levels in 2- and 6-month-old, male and female WT mice, at 12 p.m. and 8 p.m., and C57Bl/6 or 129SV WT mice after foot shocks. (F) Serum Ocn levels in WT female rats after restraint. (G) Serum Ocn levels in WT mice after foot shock and humans after public speaking stress. (H) Serum Ocn levels in WT mice after TMT or rabbit urine exposure. (I) Serum Ocn and corticosterone levels in TMT-exposed WT mice (gray). (J) Serum Ocn levels and rate of Ocn release in TMT-exposed WT mice expressing hM4Di in the BLA after injection of CNO or vehicle. Mice are 3-month-old females unless otherwise specified. Values are mean ±SEM. ns, not significant; *, p<.05; **, p<.01; by Student’s t-test or one-way ANOVA with Bonferroni post hoc test.