Figure 6.

KUS121 Treatment After Reperfusion Also Maintains ATP Levels in Ischemia and Reperfusion Injury Models

(A) Representative pseudocolor ratiometric fluorescence resonance energy transfer (FRET) images of whole hearts in I/R injury models of Go-ATeam2 mice. Pseudocolor images were obtained at various time points in ischemia and after reperfusion. In pseudocolor images, warmer colors represent high FRET ratios and cooler colors represent low FRET ratios. (B) Quantification of ATP levels in the infarcted area by FRET ratio (control group, n = 7; KUS121 group, n = 8). *p < 0.05, using unpaired 2-tailed Student’s t-test. Data are presented as mean ± SEM. Abbreviations as in Figures 2, 3, and 4.