Figure 4.

The Simulated Progression of Different Types of Psoriatic Lesions

Rows 1–3: Development of the lesions. The earliest stage of a papule (Row 1) consists of randomly distributed small seed areas. Later forms of the disease (Rows 2 and 3) correspond to patterns identified in Figures 1 and 3. Rows 4–6: The effect of treatment simulated by increasing the decay rate of IL-17 and TNF-α. Note that the treatment does not result in a simple reversal of the original pattern development, but produces residual lesions with more activity at the margin of the plaques (Row 5). In some instances, residual papules persist (Row 6).