Table 1.

Patient Demographics and Infection Source

Characteristic	MARS (n = 198)	VENUS (n = 129)	VENUS Supplement (n = 120)	Total (N = 447)
Age, yr, median (IQR)	59.5 (46–71)	61.0 (48–70)	57.0 (43.8–68)	59.0 (46–70)
Sex, n (%)
Female	75 (16.8)	62 (13.9)	55 (12.3)	192 (43.0)
Male	123 (27.5)	67 (15.0)	65 (14.5)	255 (57.0)
Race/ethnicity, n (%)
White	154 (34.4)	117 (26.2)	45 (10.1)	316 (70.7)
Black	26 (5.8)	1 (0.2)	61 (13.6)	88 (19.7)
Asian	14 (3.1)	3 (0.7)	7 (1.6)	24 (5.4)
Hispanic	0 (0.0)	5 (1.1)	7 (1.6)	12 (2.7)
Other/unknown	4 (0.9)	3 (0.7)	0 (0.0)	7 (1.6)
Infection source, n (%)
Pneumonia	44 (9.8)	17 (3.8)	25 (5.6)	86 (19.2)
UTI	16 (3.6)	10 (2.2)	1 (0.2)	27 (6.0)
Bloodstream	0 (0.0)	8 (1.8)	10 (2.2)	18 (4.0)
Abdominal	25 (5.6)	6 (1.3)	6 (1.3)	37 (8.3)
Other	16 (3.6)	12 (2.7)	10 (2.2)	38 (8.5)
Not identified initially	97 (21.7)	76 (17.0)	68 (15.2)	241 (53.9)
Classification: unanimous RPD, n (%)
Sepsis	50 (11.2)	35 (7.8)	34 (7.6)	119 (26.6)
SIRS	65 (14.5)	49 (11.0)	57 (12.8)	171 (38.2)
Indeterminate	NA	NA	NA	NA
Classification: consensus RPD, n (%)
Sepsis	81 (18.1)	55 (12.3)	44 (9.8)	180 (40.3)
SIRS	100 (22.4)	65 (14.5)	65 (14.7)	230 (51.4)
Indeterminate	17 (3.8)	9 (2.0)	11 (2.4)	37 (8.3)
Classification: forced RPD, n (%)
Sepsis	90 (20.1)	59 (13.2)	53 (11.9)	202 (45.2)
SIRS	108 (24.2)	70 (15.7)	67 (15.0)	245 (54.8)
Indeterminate	NA	NA	NA	NA

Definition of abbreviations: IQR = interquartile range; MARS = Molecular Diagnosis and Risk Stratification of Sepsis; NA = not applicable; RPD = retrospective physician diagnosis; SIRS = systemic inflammatory response syndrome; UTI = urinary tract infection; VENUS = Validation of Septic Gene Expression Using SeptiCyte.

Classification is by consensus RPD, unless indicated otherwise.