Table 2.
Patient Clinical Characteristics
|
P Value* (Sepsis vs. SIRS) |
|||||
|---|---|---|---|---|---|
| Characteristic | Sepsis (n = 180) | SIRS (n = 230) | Indeterminate (n = 37) | t Test | Mann-Whitney U Test |
| ICU LOS, d | 2.8 (1.7–5.8) | 1.9 (1.2–3.1) | 2.8 (1.3–6.8) | 7.0 × 10−6 | 3.2 × 10−7 |
| Hospital LOS, d | 7.4 (3.5–11.4) | 3.7 (2.6–6.6) | 6.4 (3.5–10.7) | 1.5 × 10−5 | 3.1 × 10−9 |
| SOFA score | 7.0 (4.8– 9.0) | 6.0 (4.0–8.0) | 5.0 (3.0–9.0) | 3.0 × 10−3 | 1.1 × 10−2 |
| WBC count, ×10−6 cells/ml, maximum | 15.0 (9.8–21.4) | 13.2 (8.8–17.4) | 13.7 (10.4–15.7) | 3.5 × 10−4 | 6.9 × 10−3 |
| Temperature, °C, maximum | 38 (37–39) | 37 (37–38) | 37 (37–38) | 1.2 × 10−8 | 9.0 × 10−8 |
| Heart rate, beats/min, maximum | 122 (109–136) | 113 (99–131) | 116 (103–129) | 6.8 × 10−4 | 1.5 × 10−4 |
| Respiratory rate, breaths/min | 24.0 (20.5–28.0) | 21.5 (18.5–25.0) | 24.4 (22.0–26.0) | <1.0 × 10−3 | 3.0 × 10−4 |
| PaO2, mm Hg | 75.0 (65.9–92.2) | 89.5 (68.0–119.2) | 80.5 (69.5–90.4) | 1.0 × 10−3 | 1.5 × 10−3 |
| Mean arterial pressure, mm Hg, minimum | 57 (49–64) | 64 (55–75) | 63 (58–73) | 3.7 × 10−7 | 1.2 × 10−7 |
| Lactate, mmol/L | 2.4 (1.6–4.0) | 2.1 (1.4–3.3) | 2.7 (1.6–3.5) | NS (0.57) | NS (0.22) |
| Creatinine, mg/dl | 5.4 (1.1–115.0) | 3.2 (1.0–81.8) | 3.7 (0.8–78.8) | NS (0.60) | NS (0.19) |
| Procalcitonin, ng/ml | 6.9 (1.6–24.0) | 0.3 (0.1–1.7) | 0.6 (0.1–5.0) | 8.4 × 10−7 | 6.1 × 10−20 |
| SeptiScore | 6.6 (5.2–7.7) | 3.7 (2.6–4.7) | 4.5 (2.9–6.0) | 4.1 × 10−40 | 2.2 × 10−34 |
| Mechanical ventilation, n (%) | 69 (15.4) | 102 (22.8) | 18 (4.0) | NS (0.06) (Z-score test) |
|
| Death, n (%) | 28 (6.3) | 27 (6.0) | 3 (0.7) | NS (0.90) (Z-score test) |
|
| SeptiScore band 1, n (%) | 10 (5.6) | 79 (34.3) | 10 (27.0) | ||
| SeptiScore band 2, n (%) | 20 (11.1) | 82 (35.6) | 6 (16.2) | ||
| SeptiScore band 3, n (%) | 45 (25.0) | 49 (21.3) | 11 (29.7) | ||
| SeptiScore band 4, n (%) | 105 (58.3) | 20 (8.7) | 10 (27.0) | ||
Definition of abbreviations: LOS = length of stay; NS = not significant; SIRS = systemic inflammatory response syndrome; SOFA = Sequential Organ Failure Assessment; WBC = white blood cell.
Consensus retrospective physician diagnosis was used to determine the patient numbers in the categories. Data are shown as median (interquartile range) unless otherwise noted.
*
For all parameters except mechanical ventilation and death, statistical significance was assessed with both Student’s t test (Microsoft Excel) and the Mann-Whitney U test (http://astatsa.com/WilcoxonTest/). For mechanical ventilation and death, a two-tailed Z-score test for difference in proportions was used (http://epitools.ausvet.com.au).