Table 3.

Summary of Results from Binary Analysis of Complete Clinical Dataset

RPD	Description	Sepsis Prevalence	AUC	Sensitivity	Specificity	NPV	PPV
Unanimous, based on discharge evaluation (n = 290 of 447 [64.9%])	All three panelists and site PI agree on SIRS (171 of 290 [59.0%]) or sepsis (119 of 290 [41.0%])	41.0%	0.89	0.97	0.34	0.94	0.51
Consensus (n = 410 of 447 [91.7%])	Majority vote leads to exclusion of 37 indeterminates and classification of 230 of 410 (56.1%) as SIRS and 180 of 410 (43.9%) as sepsis	43.9%	0.85	0.94	0.35	0.89	0.53
Forced (n = 447 of 447 [100.0%])	All subjects classified as SIRS (245 of 447 [54.8%]) or sepsis (202 of 447 [45.2%])	45.2%	0.82	0.92	0.65	0.91	0.69

Definition of abbreviations: AUC = area under the curve; NPV = negative predictive value; PI = principal investigator; PPV = positive predictive value; RPD = retrospective physician diagnosis; SIRS = systemic inflammatory response syndrome.

A SeptiCyte LAB cutoff value of 3.1 was used in the analysis. This value had been obtained previously from receiver operating curve analysis of an independent discovery dataset (4).