Table S3. Multivariable Cox proportional hazards model 4 for PFS.

Variables	Subgroups	P value	HR (95%CI)
Age, years	≥70 vs. <70	0.003	0.290 (0.130, 0.646)
Gender	Female vs. male	0.572	0.893 (0.603, 1.322)
Number of sites of metastases	>3 vs. ≤3	0.012	1.446 (1.084, 1.930)
Smoking history	Once or now smoking vs. non-smoker	0.990	1.002 (0.690, 1.457)
Previous chest radiotherapy	Yes vs. no	0.034	0.639 (0.422, 0.967)
Surgical history	Yes vs. no	0.006	0.672 (0.506, 0.892)
Number of previous chemotherapy regimens	≥3 vs. 2	0.205	1.209 (0.902, 1.620)
	1 vs. 2	0.566	0.653 (0.153, 2.797)
ECOG PS	1 vs. 0	0.668	0.927 (0.657,1.309)
	2 vs. 0	0.670	1.584 (0.191, 13.109)
Histology	Squamous vs. non-squamous	0.632	1.096 (0.754, 1.594)
Driver gene	Positive vs. negative	0.630	1.079 (0.792, 1.470)
Previous antiangiogenic therapy	Yes vs. no	0.253	1.495 (0.751, 2.975)

PFS, progression-free survival.